sábado, 17 de setembro de 2011

What's new for 'ACE inhibitors and cancer' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology
Sender's message:
Sent on Saturday, 2011 Sep 17
Search angiotensin cancer


PubMed Results
Item 1 of 1

1.Angiotensin converting enzyme inhibitors and hepatocellular carcinoma incidence in the General Practice Research Database.

Walker AJ, West J, Grainge MJ, Card TR.

Cancer Causes Control. 2011 Sep 11. [Epub ahead of print]

Abstract

OBJECTIVE:

Laboratory findings demonstrate anticancer effects of angiotensin converting enzyme (ACE) inhibitors, including anti-angiogenic activity and inhibition of liver cancer growth in rodent models. Small studies in humans indicate potential for therapeutic anticancer effects and warrant further larger studies.

METHODS:

A case-control study using the General Practice Research Database examined whether prior ACE inhibitor usage was associated with a reduction in incidence of hepatocellular carcinoma (HCC).

RESULTS:

Two hundred twenty-four HCC cases were identified, each matched to up to 10 controls by age, sex, and general practice. The data show that HCC is associated with a small, nonsignificant increase in prior use of ACE inhibitors (OR = 1.16, CI = 0.67-2.00). ACE inhibitor use was 7.1% (of 224) in cases and 5.9% (of 2,313) in controls. No significant effects were found when investigating the effect of dose and exposure duration.

CONCLUSIONS:

We found no clear protective effect of ever or long term use of ACE inhibitors against the development of HCC. Our study suggests that it is unlikely that this class of drugs will be a clinically useful cancer chemoprevention therapy.

PMID: 21909951 [PubMed - as supplied by publisher]


Clique aqui!

2015 A.C. Camargo academic journals acesso aberto adverse drug reactions alergia alquilantes alto custo ambiente ambientes virtuais analgésicos anomalias vasculares anti-eméticos anti-helmínticos anti-histamínico antianêmicos antiangiogênico anticâncer anticoagulantes antifúngicos antiprotozoários antivirais artemisinina arXiv asma asthma atopia atualização aula aulas auto-arquivamento avastin avermectina bevacizumab biologicals bioRxiv Blogger brain tumor bundler cancer cancerologia pediátrica Carlos Chagas carne vermelha cauterização Ceará CERN child chronic fatigue syndrome ciência ciência brasileira ciências biológicas e da saúde cientistas influentes cirurgia CLI Command Line Tools conselho internacional crime virtual CT scans Curtis Harris darbopoietina dermatite desenvolvedor diabetes dieta disautonomia dislipidemias doença renal doenças cardíacas doenças parasitárias dor DPOC eczema editoras predatórias efeitos adversos eficácia ensino e pesquisa eritropoietina erlotinib ESA escleroterapia estatinas esteróides estilo de vida exercícios F1000Research farmacogenética farmacologia fatores de crescimento fibromialgia Figshare Fisiologia e Medicina fitness flu FMJ Fortaleza fosfoetanolamina fraude acadêmica fraude eletrônica genetics GitHub glioblastoma gliomas Google Books Google mapas gordos green way Harald zur Hausen hemangiomas hemophagocytic lymphohistiocytosis High Sierra homebrew horário imagem immunology imunossupressores imunoterapia infecção urinária inibidores de ECA inibidores tirosina-quinase iniciação científica insulina irracionalismo ivermectina Jeffrey Beall Jekyll journal hijack Lectures lepra leucemia leukemia linfangiomas Mac OS Mac OS X macrophage activation syndrome magrinhas mal-formações March for Science Marcha pela Ciência medicina personalizada meta-análise Milton Santos modelos monoclonais monoclonal antibody mortalidade morte mudança Mulliken neuro-oncologia neuroblastoma neurology ngram viewer Nobel Nobel em Medicina ou Fisiologia novas drogas novos tratamentos obesidade ômega 3 open access open science OpenAIRE osteoporose Osvaldo Cruz package installer pediatria pediatric cancer pediatric tumors pediatrics peer review PeerJ personalized medicine PET/CT pharmacogenetics pharmacological treatment pharmacology plágio política de C&T posters postprints predatory publishers Preprints pressão arterial prevenção progressista projeto de pesquisa propranolol próstata publicação publicação científica publicações publication pubmed Python python 2 python 3 quimioterapia radiation radioterapia rapamycin rbenv recidiva regressão espontânea Regulação médica repository resposta resultados retrospectiva revisão por pares risco Ruby Satoshi Ömura Scholarly Open Access science ScienceNOW seguimento selênio self-archiving sequestro de periódico científico serotonina SIDA sildenafil slides sobrevida sulfa suplementos survival tacerva targeted therapy temozolamida temozolomide terapia alternativa tireóide tratamento tuberculose tumores cerebrais tumores pediátricos vaccine vacina venv via dourada via verde virtualenv virtualenvwrapper vitamina E vitaminas William C. Campbell Xcode Youyou Tu Zenodo

Postagens populares