What's new for 'ACE inhibitors and cancer' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology
Sender's message:
Sent on Saturday, 2011 Sep 17
Search angiotensin cancer

PubMed Results

Item 1 of 1

1.	Angiotensin converting enzyme inhibitors and hepatocellular carcinoma incidence in the General Practice Research Database.
	Walker AJ, West J, Grainge MJ, Card TR.
	Cancer Causes Control. 2011 Sep 11. [Epub ahead of print]
	Abstract OBJECTIVE: Laboratory findings demonstrate anticancer effects of angiotensin converting enzyme (ACE) inhibitors, including anti-angiogenic activity and inhibition of liver cancer growth in rodent models. Small studies in humans indicate potential for therapeutic anticancer effects and warrant further larger studies. METHODS: A case-control study using the General Practice Research Database examined whether prior ACE inhibitor usage was associated with a reduction in incidence of hepatocellular carcinoma (HCC). RESULTS: Two hundred twenty-four HCC cases were identified, each matched to up to 10 controls by age, sex, and general practice. The data show that HCC is associated with a small, nonsignificant increase in prior use of ACE inhibitors (OR = 1.16, CI = 0.67-2.00). ACE inhibitor use was 7.1% (of 224) in cases and 5.9% (of 2,313) in controls. No significant effects were found when investigating the effect of dose and exposure duration. CONCLUSIONS: We found no clear protective effect of ever or long term use of ACE inhibitors against the development of HCC. Our study suggests that it is unlikely that this class of drugs will be a clinically useful cancer chemoprevention therapy. PMID: 21909951 [PubMed - as supplied by publisher]

What's new for 'cancer' in PubMed

From Pubmed latest published:

Cytarabine dose of 36 g/m² compared with 12 g/m² within first consolidation in acute myeloid leukemia: results of patients enrolled onto the prospective randomized AML96 study.
Schaich M, Röllig C, Soucek S, Kramer M, Thiede C, Mohr B, Oelschlaegel U, Schmitz N, Stuhlmann R, Wandt H, Schäfer-Eckart K, Aulitzky W, Kaufmann M, Bodenstein H, Tischler J, Ho A, Krämer A, Bornhäuser M, Schetelig J, Ehninger G.
J Clin Oncol. 2011 Jul 1;29(19):2696-702. Epub 2011 May 23.

This study showed that higher cytarabine dose did not associated with better results than standard dose in AML consolidation chemotherapy.
Link: http://bit.ly/qIuDwd

What's new for 'fibromyalgia' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology
Sender's message: Search: fibromyalgia
Sent on Saturday, 2011 Sep 10
Search fibromyalgia

(Selected results only)

PubMed Results

1.	Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia.
	Smith SB, Maixner DW, Fillingim RB, Slade G, Gracely RH, Ambrose K, Zaykin DV, Hyde C, John S, Tan K, Maixner W, Diatchenko L.
	Arthritis Rheum. 2011 Sep 8. doi: 10.1002/art.33338. [Epub ahead of print]
	PMID: 21905019 [PubMed - as supplied by publisher] Comment: this breakthrough study reveals gene candidates for causing fibromyalgia - interstingly most of them relates somewhat to descending pain control that occurs in supraspinal neural centers, highlighting the critical importance of this phenomenon to fibromyalgia (comment added by the blogger).

2.	Association of fibromyalgia characteristics in patients with non-metastatic breast cancer and the protective role of resilience.
	Schrier M, Amital D, Arnson Y, Rubinow A, Altaman A, Nissenabaum B, Amital H.
	Rheumatol Int. 2011 Sep 8. [Epub ahead of print]
	PMID: 21901352 [PubMed - as supplied by publisher]

3.	Psychological distress in fibromyalgia patients: A role for Catechol-O-Methyl-Transferase Val158Met polymorphism.
	Desmeules J, Piguet V, Besson M, Chabert J, Rapiti E, Rebsamen M, Rossier MF, Curtin F, Dayer P, Cedraschi C.
	Health Psychol. 2011 Sep 5. [Epub ahead of print]
	PMID: 21895373 [PubMed - as supplied by publisher] Comment: fibromyalgia is now recognized as a disease with a molecular background that has been explored in the last few years. One can say that it is a disease with a pain modulation, processing and perception alteration that leads to chronic pain. Cathecolaminergic signaling is central to its pathogenesis and this is the basis of the most used pharmacological treatments used in the last years. The author of this blog has published commentaries and reviews about this topic in peer-reviewed journals. You can check this following the link to my CV: http://bit.ly/oH8Bfu

What's new for 'cancer' in PubMed

Search cancer

Limits:Randomized Controlled Trial, All Child: 0-18 years

PubMed Results

Items 1 - 4 of 4

1.	Randomized phase II study comparing gemcitabine plus dacarbazine versus dacarbazine alone in patients with previously treated soft tissue sarcoma: a Spanish Group for Research on Sarcomas study.
	García-Del-Muro X, López-Pousa A, Maurel J, Martín J, Martínez-Trufero J, Casado A, Gómez-España A, Fra J, Cruz J, Poveda A, Meana A, Pericay C, Cubedo R, Rubió J, De Juan A, Laínez N, Carrasco JA, de Andrés R, Buesa JM; Spanish Group for Research on Sarcomas.
	J Clin Oncol. 2011 Jun 20;29(18):2528-33. Epub 2011 May 23.
	PMID: 21606430 [PubMed - indexed for MEDLINE]
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2.	Role of chemoradiotherapy in intermediate prognosis nasopharyngeal carcinoma.
	Xu T, Hu C, Wang X, Shen C.
	Oral Oncol. 2011 May;47(5):408-13. Epub 2011 Apr 2.
	PMID: 21459659 [PubMed - indexed for MEDLINE]
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3.	Patient-reported Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales in pediatric patients with attention-deficit/hyperactivity disorder and comorbid psychiatric disorders: feasibility, reliability, and validity.
	Limbers CA, Ripperger-Suhler J, Heffer RW, Varni JW.
	Value Health. 2011 Jun;14(4):521-30. Epub 2011 Apr 22.
	PMID: 21315637 [PubMed - indexed for MEDLINE]
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4.	[Immunophenotypic features in 143 cases of acute promyelocytic leukemia].
	Sun HM, Qian SX, Wu YJ, Qiao C, Hong M, Fan L, Yang H, Zhang JF, Zhang SJ, Wu HX, Qiu HX, Lu H, Xu W, Sheng RL, Li JY.
	Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):176-9. Chinese.
	PMID: 19236773 [PubMed - indexed for MEDLINE]
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What's new this month for 'macrophage activation syndrome' in PubMed

This message contains My NCBI what's new results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM).

Sender's message: Search: macrophage activation syndrome
Sent on Saturday, 2011 Jul 02
Search macrophage activation syndrome

PubMed Results

1.	Adult-onset Still's disease with macrophage activation syndrome successfully treated with a combination of methotrexate and etanercept.
	Maeshima K, Ishii K, Iwakura M, Akamine M, Hamasaki H, Abe I, Haranaka M, Tatsukawa H, Yoshimatsu H.
	Mod Rheumatol. 2011 Jun 14. [Epub ahead of print]
	PMID: 21670967 [PubMed - as supplied by publisher]
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2.	Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.
	Mellins ED, Macaubas C, Grom AA; Medscape.
	Nat Rev Rheumatol. 2011 Jun 7;7(7):416-26. doi: 10.1038/nrrheum.2011.68.
	PMID: 21647204 [PubMed - in process]
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3.	Immune mobilization of autologous blood progenitor cells: direct influence on the cellular subsets collected.
	Meehan KR, Talebian L, Wu J, Hill JM, Szczepiorkowski ZM, Sentman CL, Ernstoff MS.
	Cytotherapy. 2010 Dec;12(8):1013-21. Epub 2010 Sep 27.
	PMID: 20873991 [PubMed - indexed for MEDLINE]
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