sexta-feira, 16 de setembro de 2011

The Enemy Within - Unexpected Cell Type Orchestrate Immune Turmoil in Flu - via ScienceNow

When a patient gets killed by a specially lethal kind of flu, as in the recent outbreaks of H1N1 or H5N1 (swine and avian) strains of flu virus, it might be the body's own defenses that make the final move. The flu and other infections can provoke so-called cytokine storms or immunological storms. One hallmark of these events is a surge of chemical messengers called cytokines and chemokines into tissues and the blood, promoting inflammation. Immune cells, including macrophages and natural killer cells, also flood the lungs. The combination can cause fatal disease with lung and other organs damage. Some flu strains might initiate more often these immune waves. For example, animal studies suggest that the Spanish flu virus (the one that killed millions in the 1918 epidemia) makes the immune system overaggressive. Cells that line the lungs and airways and the immune cells that move in after infection are responsible for cytokine storms—or at least that's what researchers thought.

A team led by chemical biologist Hugh Rosen and virologist Michael Oldstone of the Scripps Research Institute in San Diego, California, investigated the S1P pathway, a molecular control circuit that fine-tunes immune responses. The scientists gave influenza-infected rodents a compound that stimulates the S1P1 receptor. The treatment prevented a cytokine outburst and reduced movement of immune cells into the lungs. When the researchers looked after the cells in the lungs that carry the S1P1 receptor, they found that it occurs on endothelial cells, which line lymphatic and blood vessels, and on the white blood cells known as lymphocytes. To determine which of these two cell types controls the cytokine surge, the researchers tested the S1P1 receptor activator in genetic modified mice that lack lymphocytes. The compound also prevented the storms in these animals, suggesting that endothelial cells, not lymphocytes, orchestrate cytokine release. This fascinating finding opens a whole new avenue of research into flu and potentially many other infectious and inflammatory diseases, where endothelial cells may have a previously unknown important role.

Read the post on ScienceNow:
Surprising Cells Rein In Killer Flu - ScienceNOW - http://bit.ly/pe8PUo

Clique aqui!

2015 A.C. Camargo academic journals acesso aberto adverse drug reactions alergia alquilantes alto custo ambiente analgésicos anomalias vasculares anti-eméticos anti-helmínticos anti-histamínico antianêmicos antiangiogênico anticâncer anticoagulantes antifúngicos antiprotozoários antivirais artemisinina arXiv asma asthma atopia atualização aula aulas auto-arquivamento avastin avermectina bevacizumab biologicals bioRxiv Blogger brain tumor cancer cancerologia pediátrica Carlos Chagas carne vermelha cauterização Ceará child chronic fatigue syndrome ciência ciência brasileira ciências biológicas e da saúde cientistas influentes cirurgia CLI conselho internacional crime virtual CT scans Curtis Harris darbopoietina dermatite diabetes dieta disautonomia dislipidemias doença renal doenças cardíacas doenças parasitárias dor DPOC eczema editoras predatórias efeitos adversos eficácia ensino e pesquisa eritropoietina erlotinib ESA escleroterapia estatinas esteróides estilo de vida exercícios F1000Research farmacogenética farmacologia fatores de crescimento fibromialgia Figshare Fisiologia e Medicina fitness flu FMJ fosfoetanolamina fraude acadêmica fraude eletrônica genetics glioblastoma gliomas Google Books gordos green way Harald zur Hausen hemangiomas hemophagocytic lymphohistiocytosis horário imagem immunology imunossupressores imunoterapia infecção urinária inibidores de ECA inibidores tirosina-quinase iniciação científica insulina irracionalismo ivermectina Jeffrey Beall journal hijack Lectures lepra leucemia leukemia linfangiomas Mac OS X macrophage activation syndrome magrinhas mal-formações March for Science Marcha pela Ciência medicina personalizada meta-análise Milton Santos modelos monoclonais monoclonal antibody mortalidade morte mudança Mulliken neuro-oncologia neuroblastoma neurology ngram viewer Nobel Nobel em Medicina ou Fisiologia novas drogas novos tratamentos obesidade ômega 3 open access osteoporose Osvaldo Cruz pediatria pediatric cancer pediatric tumors pediatrics peer review PeerJ personalized medicine PET/CT pharmacogenetics pharmacological treatment pharmacology plágio política de C&T posters postprints predatory publishers Preprints pressão arterial prevenção progressista projeto de pesquisa propranolol próstata publicação publicação científica publicações publication pubmed Python quimioterapia radiation radioterapia rapamycin recidiva regressão espontânea resposta resultados retrospectiva revisão por pares risco Satoshi Ömura Scholarly Open Access science ScienceNOW seguimento selênio self-archiving sequestro de periódico científico serotonina SIDA sildenafil slides sobrevida sulfa suplementos survival tacerva targeted therapy temozolamida temozolomide terapia alternativa tireóide tratamento tuberculose tumores cerebrais tumores pediátricos vaccine vacina via dourada via verde vitamina E vitaminas William C. Campbell Youyou Tu

Postagens populares