sábado, 23 de abril de 2011

News in pediatric oncology - new treatment for relapsed ALL and more

In the few past months important new discoveries from clinical trials in pediatric hemato-oncology were published. We list some of the most outstanding:
1. Mitoxantrone for relapsed ALL - UK Children's Cancer Group reported in Lancet last December that children with relapsed ALL (a disease with poor prognosis, in contrast with primary ALL which is highly curable) benefited from treatment with the drug mitoxantrone, when compared with the standard therapy with idarubicin. Survival in children with relapsed ALL was 69% (overall) and 65% (progression-free), whereas the standard treatment yielded 36-45% survival. Link here.
2. Second-look surgery for RMS - Children's Oncology Group reported last November in the Journal of Pediatric Surgery that children with rhabdomyosarcoma may benefit from second-look surgical procedures in order to check local control rates. Image-proven complete remissions were reliable in this study, but 41% of patients with residual disease by image had no viable tumor in second-look procedure. Patients with no viable disease had a better failure-free survival in this study. Link here.
3. Beta-2 adrenergic receptor and ALL - French researchers reported this December that genetic polymorphisms in the promoter region of the gene encoding the beta-2 adrenergic receptor reliably correlate with relapse and response rate to methotrexate. The beta-2 adrenoceptor, mostly known by its involvement in smooth muscle contraction, is part of a proapoptotic signaling pathway, and thus its expression by cancer can possibly influence drug resistance. Link here.


Clique aqui!

2015 A.C. Camargo academic journals acesso aberto adverse drug reactions alergia alquilantes alto custo ambiente ambientes virtuais analgésicos anomalias vasculares anti-eméticos anti-helmínticos anti-histamínico antianêmicos antiangiogênico anticâncer anticoagulantes antifúngicos antiprotozoários antivirais artemisinina arXiv asma asthma atopia atualização aula aulas auto-arquivamento avastin avermectina bevacizumab biologicals bioRxiv Blogger brain tumor bundler cancer cancerologia pediátrica Carlos Chagas carne vermelha cauterização Ceará CERN child chronic fatigue syndrome ciência ciência brasileira ciências biológicas e da saúde cientistas influentes cirurgia CLI Command Line Tools conselho internacional crime virtual CT scans Curtis Harris darbopoietina dermatite desenvolvedor diabetes dieta disautonomia dislipidemias doença renal doenças cardíacas doenças parasitárias dor DPOC eczema editoras predatórias efeitos adversos eficácia ensino e pesquisa eritropoietina erlotinib ESA escleroterapia estatinas esteróides estilo de vida exercícios F1000Research farmacogenética farmacologia fatores de crescimento fibromialgia Figshare Fisiologia e Medicina fitness flu FMJ Fortaleza fosfoetanolamina fraude acadêmica fraude eletrônica genetics GitHub glioblastoma gliomas Google Books Google mapas gordos green way Harald zur Hausen hemangiomas hemophagocytic lymphohistiocytosis High Sierra homebrew horário imagem immunology imunossupressores imunoterapia infecção urinária inibidores de ECA inibidores tirosina-quinase iniciação científica insulina irracionalismo ivermectina Jeffrey Beall Jekyll journal hijack Lectures lepra leucemia leukemia linfangiomas Mac OS Mac OS X macrophage activation syndrome magrinhas mal-formações March for Science Marcha pela Ciência medicina personalizada meta-análise Milton Santos modelos monoclonais monoclonal antibody mortalidade morte mudança Mulliken neuro-oncologia neuroblastoma neurology ngram viewer Nobel Nobel em Medicina ou Fisiologia novas drogas novos tratamentos obesidade ômega 3 open access open science OpenAIRE osteoporose Osvaldo Cruz package installer pediatria pediatric cancer pediatric tumors pediatrics peer review PeerJ personalized medicine PET/CT pharmacogenetics pharmacological treatment pharmacology plágio política de C&T posters postprints predatory publishers Preprints pressão arterial prevenção progressista projeto de pesquisa propranolol próstata publicação publicação científica publicações publication pubmed Python python 2 python 3 quimioterapia radiation radioterapia rapamycin rbenv recidiva regressão espontânea Regulação médica repository resposta resultados retrospectiva revisão por pares risco Ruby Satoshi Ömura Scholarly Open Access science ScienceNOW seguimento selênio self-archiving sequestro de periódico científico serotonina SIDA sildenafil slides sobrevida sulfa suplementos survival tacerva targeted therapy temozolamida temozolomide terapia alternativa tireóide tratamento tuberculose tumores cerebrais tumores pediátricos vaccine vacina venv via dourada via verde virtualenv virtualenvwrapper vitamina E vitaminas William C. Campbell Xcode Youyou Tu Zenodo

Postagens populares