The administration of multipotent adult progenitor cells (MAPC) after a spinal cord injury in rodent models prevents shrinkage of neurons, reported a team from Cleveland, Ohio. Inhibition of this process, known as regressive axonal death, reduces inflammation in the region of injury and promotes regeneration of neurons.
This study shows that adult stem cells are able to modify certain aspects of the response after spinal cord injury and also may alter the inflammatory response to mitigate collateral damage in the central nervous system and increase the regenerative capacity of damaged neurons.
MAPC administration significantly decreased the release of a damaging protein called MMP-9 by macrophages. It also induced a change in the macrophages of M1 to M2 and also promoted the growth of sensory neurites beyond the site of injury, inducing their formation. It also allowed the axons to overcome the negative effects of macrophages and inhibitory molecules in their environment, increasing intrinsic growth capacity.
Read the complete report.
This study shows that adult stem cells are able to modify certain aspects of the response after spinal cord injury and also may alter the inflammatory response to mitigate collateral damage in the central nervous system and increase the regenerative capacity of damaged neurons.
MAPC administration significantly decreased the release of a damaging protein called MMP-9 by macrophages. It also induced a change in the macrophages of M1 to M2 and also promoted the growth of sensory neurites beyond the site of injury, inducing their formation. It also allowed the axons to overcome the negative effects of macrophages and inhibitory molecules in their environment, increasing intrinsic growth capacity.
Read the complete report.
Nenhum comentário:
Postar um comentário